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Alteration in sperm characteristics, endocrine balance and redox status in rats rendered diabetic by streptozotocin treatment: attenuating role of Loranthus micranthus
Ebokaiwe, Azubuike P.1,5; Ijomone, Omamuyovwi M.2; Osawe, Sharon O.3; Chukwu, Chukwuma J.1; Ejike, Chukwunonso E. C. C.4; Zhang, Guolin5; Wang, Fei5
Corresponding AuthorEbokaiwe, Azubuike P.(petazk@yahoo.com)
2018
Source PublicationREDOX REPORT
ISSN1351-0002
Volume23Issue:1Pages:194-205
AbstractObjectives: Loranthus micranthus is widely used in Nigerian folklore treatment of male infertility and diabetes complications. We investigated this claim in rats rendered diabetic by streptozotocin (STZ). Methods: Induction of diabetes mellitus in adult male Wistar rats was by intraperitoneal injection of STZ (60 mg/kg). The diabetic rats were thereafter treated orally once/day with 5 mg/kg Gilbenclamide or L. micranthus (100 mg/kg or 200 mg/kg) and monitored for 14 days. Clinical observations, hormonal profile, oxidative stress parameters, glucose metabolism enzymes, histopathological examination, apoptotic marker immunoreactivity and western blotting in testes and sperm parameters were evaluated to examine effects of L. micranthus on STZ-diabetic rats. Results: L. micranthus treatment significantly reduced the blood glucose level (45.9% and 84.7% on the 7th and 14th post-treatment days, respectively); increased antioxidant status, improved microarchitecture of testes, reduced lipid peroxidation and increased BCI-2 protein expression in diabetic rats relative to control. Furthermore, treatment with L. micranthus increased steroidogenic enzymes activities, levels of steroid hormones and improved sperm quality, relative to control. Conclusion: The anti-diabetic and aphrodisiac properties exhibited by L. micranthus could be contingent on its ability to restore a balance to the compromised redox status that characterizes male reproductive dysfunction in diabetes.
KeywordLoranthus micranthus spermiogram diabetes oxidative stress apoptosis steroid hormones male rats
DOI10.1080/13510002.2018.1540675
Indexed BySCI
WOS KeywordHIGH-ENERGY DIETS ; ANTIOXIDANT ACTIVITY ; INSULIN-RESISTANCE ; GLUCOSE ; CALCIFICATION ; CAPACITATION ; TESTOSTERONE ; INFLAMMATION ; POLYPHENOLS ; GLUTATHIONE
Language英语
Funding ProjectFUNAI Institutional based TETFUND grant[FUNAI/FST/14/B2/022] ; Chinese Academy of Science President's International Fellowship for Postdoctoral Researchers[2018PB0017]
WOS Research AreaBiochemistry & Molecular Biology
WOS SubjectBiochemistry & Molecular Biology
WOS IDWOS:000451191400001
Funding OrganizationFUNAI Institutional based TETFUND grant ; Chinese Academy of Science President's International Fellowship for Postdoctoral Researchers
PublisherTAYLOR & FRANCIS LTD
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.imde.ac.cn/handle/131551/24562
Collection中国科学院水利部成都山地灾害与环境研究所
Corresponding AuthorEbokaiwe, Azubuike P.
Affiliation1.Fed Univ Ndufu Alike Ikwo, Dept Chem Biochem & Mol Biol, Ikwo, Nigeria
2.Fed Univ Technol Akure, Sch Hlth & Hlth Technol, Dept Anat, Akure, Nigeria
3.KolaDaisi Univ, Fac Appl Sci, Dept Biochem, Ibadan, Nigeria
4.Fed Univ Ndufu Alike Ikwo, Coll Med, Dept Med Biochem, Ikwo, Nigeria
5.Chinese Acad Sci, Chengdu Inst Biol, Key Lab Nat Med & Clin Translat, Chengdu, Sichuan, Peoples R China
Recommended Citation
GB/T 7714
Ebokaiwe, Azubuike P.,Ijomone, Omamuyovwi M.,Osawe, Sharon O.,et al. Alteration in sperm characteristics, endocrine balance and redox status in rats rendered diabetic by streptozotocin treatment: attenuating role of Loranthus micranthus[J]. REDOX REPORT,2018,23(1):194-205.
APA Ebokaiwe, Azubuike P..,Ijomone, Omamuyovwi M..,Osawe, Sharon O..,Chukwu, Chukwuma J..,Ejike, Chukwunonso E. C. C..,...&Wang, Fei.(2018).Alteration in sperm characteristics, endocrine balance and redox status in rats rendered diabetic by streptozotocin treatment: attenuating role of Loranthus micranthus.REDOX REPORT,23(1),194-205.
MLA Ebokaiwe, Azubuike P.,et al."Alteration in sperm characteristics, endocrine balance and redox status in rats rendered diabetic by streptozotocin treatment: attenuating role of Loranthus micranthus".REDOX REPORT 23.1(2018):194-205.
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