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Alteration in sperm characteristics, endocrine balance and redox status in rats rendered diabetic by streptozotocin treatment: attenuating role of Loranthus micranthus
Ebokaiwe, Azubuike P.1,5; Ijomone, Omamuyovwi M.2; Osawe, Sharon O.3; Chukwu, Chukwuma J.1; Ejike, Chukwunonso E. C. C.4; Zhang, Guolin5; Wang, Fei5
通讯作者Ebokaiwe, Azubuike P.(petazk@yahoo.com)
2018
发表期刊REDOX REPORT
ISSN1351-0002
卷号23期号:1页码:194-205
摘要Objectives: Loranthus micranthus is widely used in Nigerian folklore treatment of male infertility and diabetes complications. We investigated this claim in rats rendered diabetic by streptozotocin (STZ). Methods: Induction of diabetes mellitus in adult male Wistar rats was by intraperitoneal injection of STZ (60 mg/kg). The diabetic rats were thereafter treated orally once/day with 5 mg/kg Gilbenclamide or L. micranthus (100 mg/kg or 200 mg/kg) and monitored for 14 days. Clinical observations, hormonal profile, oxidative stress parameters, glucose metabolism enzymes, histopathological examination, apoptotic marker immunoreactivity and western blotting in testes and sperm parameters were evaluated to examine effects of L. micranthus on STZ-diabetic rats. Results: L. micranthus treatment significantly reduced the blood glucose level (45.9% and 84.7% on the 7th and 14th post-treatment days, respectively); increased antioxidant status, improved microarchitecture of testes, reduced lipid peroxidation and increased BCI-2 protein expression in diabetic rats relative to control. Furthermore, treatment with L. micranthus increased steroidogenic enzymes activities, levels of steroid hormones and improved sperm quality, relative to control. Conclusion: The anti-diabetic and aphrodisiac properties exhibited by L. micranthus could be contingent on its ability to restore a balance to the compromised redox status that characterizes male reproductive dysfunction in diabetes.
关键词Loranthus micranthus spermiogram diabetes oxidative stress apoptosis steroid hormones male rats
DOI10.1080/13510002.2018.1540675
收录类别SCI
关键词[WOS]HIGH-ENERGY DIETS ; ANTIOXIDANT ACTIVITY ; INSULIN-RESISTANCE ; GLUCOSE ; CALCIFICATION ; CAPACITATION ; TESTOSTERONE ; INFLAMMATION ; POLYPHENOLS ; GLUTATHIONE
语种英语
资助项目FUNAI Institutional based TETFUND grant[FUNAI/FST/14/B2/022] ; Chinese Academy of Science President's International Fellowship for Postdoctoral Researchers[2018PB0017]
WOS研究方向Biochemistry & Molecular Biology
WOS类目Biochemistry & Molecular Biology
WOS记录号WOS:000451191400001
项目资助者FUNAI Institutional based TETFUND grant ; Chinese Academy of Science President's International Fellowship for Postdoctoral Researchers
出版者TAYLOR & FRANCIS LTD
引用统计
文献类型期刊论文
条目标识符http://ir.imde.ac.cn/handle/131551/24562
专题中国科学院水利部成都山地灾害与环境研究所
通讯作者Ebokaiwe, Azubuike P.
作者单位1.Fed Univ Ndufu Alike Ikwo, Dept Chem Biochem & Mol Biol, Ikwo, Nigeria
2.Fed Univ Technol Akure, Sch Hlth & Hlth Technol, Dept Anat, Akure, Nigeria
3.KolaDaisi Univ, Fac Appl Sci, Dept Biochem, Ibadan, Nigeria
4.Fed Univ Ndufu Alike Ikwo, Coll Med, Dept Med Biochem, Ikwo, Nigeria
5.Chinese Acad Sci, Chengdu Inst Biol, Key Lab Nat Med & Clin Translat, Chengdu, Sichuan, Peoples R China
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Ebokaiwe, Azubuike P.,Ijomone, Omamuyovwi M.,Osawe, Sharon O.,et al. Alteration in sperm characteristics, endocrine balance and redox status in rats rendered diabetic by streptozotocin treatment: attenuating role of Loranthus micranthus[J]. REDOX REPORT,2018,23(1):194-205.
APA Ebokaiwe, Azubuike P..,Ijomone, Omamuyovwi M..,Osawe, Sharon O..,Chukwu, Chukwuma J..,Ejike, Chukwunonso E. C. C..,...&Wang, Fei.(2018).Alteration in sperm characteristics, endocrine balance and redox status in rats rendered diabetic by streptozotocin treatment: attenuating role of Loranthus micranthus.REDOX REPORT,23(1),194-205.
MLA Ebokaiwe, Azubuike P.,et al."Alteration in sperm characteristics, endocrine balance and redox status in rats rendered diabetic by streptozotocin treatment: attenuating role of Loranthus micranthus".REDOX REPORT 23.1(2018):194-205.
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