IMHE OpenIR
Association of Polymorphisms at the SIX1-SIX6 Locus With Primary Open-Angle Glaucoma
Lu, Shi Yao1; He, Zong Ze2; Xu, Jia Xin3; Yang, Chen4,5,6; Chen, Li Jia1; Gong, Bo4,5,6,7
Corresponding AuthorChen, Li Jia(lijia_chen@cuhk.edu.hk) ; Gong, Bo(gongbo2007@hotmail.com)
2019-07-01
Source PublicationINVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
ISSN0146-0404
Volume60Issue:8Pages:2914-2924
AbstractPURPOSE. To evaluate the association of single-nucleotide polymorphisms (SNPs) in the SIX1-SIX6 locus with primary open-angle glaucoma (POAG) through a systematic review and meta-analysis from 22 studies. METHODS. To our knowledge, all case-control association studies on SNPs in the SIX1-SIX6 locus and POAG reported up to August 30, 2018, in PubMed, Embase, and Web of Science were retrieved. Unadjusted and adjusted odds ratios (ORs) and 95% confidence intervals (95% CIs) for each SNP were calculated using a fixed- or random-effect model according to interstudy heterogeneity. RESULTS. This meta-analysis involved 12 SNPs in SIX1-SIX6 reported in 22 studies. The association of rs10483727 with POAG has been presented in 16 studies involving 14,402 patients and 27,425 controls, whereas rs33912345 has been investigated in 12 studies involving 10,563 patients and 16,740 controls. Meta-analyses revealed significant associations of these two SNPs with POAG in the pooled populations under all genetic models. Stratified analyses by population detected significant association of both SNPs in the East Asian and Caucasian subgroups, but not in South Asian or African subgroups. Among the other SNPs that were reported by up to four cohorts of East Asian and African ancestries, only rs12436579 showed a significant association in the meta-analysis (OR = 0.79, P = 1.08 x 10(-4)). CONCLUSIONS. This meta-analysis confirmed the association of rs10483727 and rs33912345 in SIX1-SIX6 with POAG. The associations of both SNPs were specifically detected in East Asian and Caucasian cohorts, rather than in South Asian and African cohorts, suggesting an ethnic difference. SNP rs12436579 is a candidate variant for the disease that awaits validation in other populations.
KeywordSIX6 POAG meta-analysis
DOI10.1167/iovs.18-26489
Indexed BySCI
WOS KeywordGENOME-WIDE ASSOCIATION ; FIBER LAYER THICKNESS ; SUSCEPTIBILITY LOCI ; GENETIC-VARIANTS ; COMMON VARIANTS ; RISK-FACTORS ; SINE-OCULIS ; SIX6 ; IDENTIFICATION ; MECHANISMS
Language英语
Funding ProjectNatural Science Foundation of China[81670853] ; Natural Science Foundation of China[81371048] ; Department of Science and Technology of Sichuan Province[2019JDJQ0031] ; General Research Fund, Hong Kong[14100917] ; General Research Fund, Hong Kong[14112514] ; foundation for Technology & Science & Technology Bureau of Chengdu[2018-YF05-00348-SN] ; Endowment Fund for Lim Por-Yen Eye Genetics Research Centre, Hong Kong
WOS Research AreaOphthalmology
WOS SubjectOphthalmology
WOS IDWOS:000474868600014
Funding OrganizationNatural Science Foundation of China ; Department of Science and Technology of Sichuan Province ; General Research Fund, Hong Kong ; foundation for Technology & Science & Technology Bureau of Chengdu ; Endowment Fund for Lim Por-Yen Eye Genetics Research Centre, Hong Kong
PublisherASSOC RESEARCH VISION OPHTHALMOLOGY INC
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.imde.ac.cn/handle/131551/26714
Collection中国科学院水利部成都山地灾害与环境研究所
Corresponding AuthorChen, Li Jia; Gong, Bo
Affiliation1.Chinese Univ Hong Kong, Dept Ophthalmol & Visual Sci, 147K Argyle St, Hong Kong, Peoples R China
2.Southwest Med Univ, Dept Neurosurg, Luzhou, Sichuan, Peoples R China
3.Southwest Med Univ, Sch Clin Med, Luzhou, Sichuan, Peoples R China
4.Sichuan Acad Med Sci, Key Lab Human Dis Gene Study Sichuan Prov, Chengdu, Sichuan, Peoples R China
5.Sichuan Acad Med Sci, Dept Lab Med, Chengdu, Sichuan, Peoples R China
6.Univ Elect Sci & Technol China, Sichuan Prov Peoples Hosp, Sch Med, Chengdu, Sichuan, Peoples R China
7.Chinese Acad Sci, Inst Chengdu Biol, Sichuan Translat Med Hosp, Chengdu, Sichuan, Peoples R China
Recommended Citation
GB/T 7714
Lu, Shi Yao,He, Zong Ze,Xu, Jia Xin,et al. Association of Polymorphisms at the SIX1-SIX6 Locus With Primary Open-Angle Glaucoma[J]. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE,2019,60(8):2914-2924.
APA Lu, Shi Yao,He, Zong Ze,Xu, Jia Xin,Yang, Chen,Chen, Li Jia,&Gong, Bo.(2019).Association of Polymorphisms at the SIX1-SIX6 Locus With Primary Open-Angle Glaucoma.INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE,60(8),2914-2924.
MLA Lu, Shi Yao,et al."Association of Polymorphisms at the SIX1-SIX6 Locus With Primary Open-Angle Glaucoma".INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 60.8(2019):2914-2924.
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