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A new cytotoxic indole alkaloid from Tabernaemontana inconspicua stapf
Laura, Gertrude Foudjo Melacheu1; Njoya, Emmanuel Mfotie2,3; Jouda, Jean-Bosco1; Kweka, Brussine Nadege Wakeu1; Mbazoa, Celine Djama1; Wang, Fei2; Seguin, Elisabeth4; Wandji, Jean1
Corresponding AuthorMbazoa, Celine Djama(editcelia@yahoo.fr)
2019-07-13
Source PublicationNATURAL PRODUCT RESEARCH
ISSN1478-6419
Pages6
AbstractOne new indole alkaloid derivative, 5,6-dioxo-11-hydroxy voacangine (1) together with four known compounds (2-5), were isolated from the fruits of Tabernaemontana contorta Stapf (Apocynaceae). Their structures were determined using 1D and 2D NMR, HRESI-MS, and a comparison with the literature. The new compound was found to be cytotoxic on human breast cancer MDA-MB 231 cells with IC50 values of 3.35 mu M and 2.19 mu M after 24 and 48 hours, respectively. [GRAPHICS] .
KeywordTabernaemontana inconspicua indole alkaloids cytotoxic activity
DOI10.1080/14786419.2019.1628749
Indexed BySCI
Language英语
Funding ProjectChinese Academy of Sciences President's International Fellowship Initiative
WOS Research AreaChemistry ; Pharmacology & Pharmacy
WOS SubjectChemistry, Applied ; Chemistry, Medicinal
WOS IDWOS:000478314300001
Funding OrganizationChinese Academy of Sciences President's International Fellowship Initiative
PublisherTAYLOR & FRANCIS LTD
Citation statistics
Document Type期刊论文
Identifierhttp://ir.imde.ac.cn/handle/131551/26914
Collection中国科学院水利部成都山地灾害与环境研究所
Corresponding AuthorMbazoa, Celine Djama
Affiliation1.Univ Yaounde I, Fac Sci, Dept Organ Chem, Yaounde, Cameroon
2.Chinese Acad Sci, Chengdu Inst Biol, Key Lab Nat Med & Clin Translat, Chengdu, Sichuan, Peoples R China
3.Univ Yaounde I, Fac Sci, Dept Biochem, Yaounde, Cameroon
4.Univ Rouen, Fac Med & Pharm, Lab Pharmacogniosie, Rouen 1, France
Recommended Citation
GB/T 7714
Laura, Gertrude Foudjo Melacheu,Njoya, Emmanuel Mfotie,Jouda, Jean-Bosco,et al. A new cytotoxic indole alkaloid from Tabernaemontana inconspicua stapf[J]. NATURAL PRODUCT RESEARCH,2019:6.
APA Laura, Gertrude Foudjo Melacheu.,Njoya, Emmanuel Mfotie.,Jouda, Jean-Bosco.,Kweka, Brussine Nadege Wakeu.,Mbazoa, Celine Djama.,...&Wandji, Jean.(2019).A new cytotoxic indole alkaloid from Tabernaemontana inconspicua stapf.NATURAL PRODUCT RESEARCH,6.
MLA Laura, Gertrude Foudjo Melacheu,et al."A new cytotoxic indole alkaloid from Tabernaemontana inconspicua stapf".NATURAL PRODUCT RESEARCH (2019):6.
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